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The SELECT trial, completed in 2023 with over 17,600 participants, showed a 20% reduction in cardiovascular events in patients with established cardiovascular disease and overweight or obesity without diabetes

Genetic predispositions in pathways like MC4R and FTO can influence both weight regulation and metabolic adaptationinsights that should be interpreted with your qualified healthcare provider

However, it also means that side effects persist for weeks after stopping, weight regain typically begins within one to two months of discontinuation, and pregnancy planning requires at least two months after your last dose