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One limitation of most PK and PD studies is the enrollment of healthy subjects, whereas the major target population for use of GLP1RAs are patients with diabetes and obesity who may have co-morbidities that might affect the PK results

doi: 10.1056/NEJMsr1809937 26 Amorim Moreira AlvesGTeranishiMTeixeira de Castro Gonalves OrtegaACJamesFPerera Molligoda ArachchigeAS

doi: 10.1016/j.diabres.2011.04.022 36 BajajHSGersteinHCRao-MelaciniPBasileJColhounHCongetIet al

The clinical management of diabetes focuses on the control of hyperglycemia using a combination of nutritional and pharmacological therapies

Moreover, uric acid serves as an oxidizable co-substrate for cyclooxygenase enzymes, thereby contributing to the reduction of oxidative stress and the maintenance of endothelial function, particularly in coronary circulation (10)