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Trimetazidine also increases pyruvate dehydrogenase activity to decrease lactate accumulation [117]

E.LambC.ZeierJ

[ [PMID: 31518657] [37] Bellows, B.K

F., Ann

The OXPHOS system is a 5-enzyme complex which encompasses the mitochondrial respiratory chain (Complexes I-IV), Complex V, and two mobile electron shuttles (coenzyme Q10 and cytochrome c)

The proposed involvement of SLC6A14 could be tested in animal models by assessing the transport of carnitine across the blood brain barrier and testing for abnormalities resulting from brain carnitine deficiency, Beaudet said