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Besides well-known oxidants or electrophiles, such as H 2 O 2 , 4-hydroxynonenal, and diethyl maleate (DEM), which also possess cytotoxicity, only few Nrf2 activators have been found to be useful in clinical trials (Sun et al
MDA is the degradation product of the main chain reactions that lead to the oxidation of polyunsaturated fatty acids, and therefore serves as an oxidative stress marker
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[14] That the same study raised both a matrix-degrading enzyme and its inhibitors is itself telling: it suggests a coordinated remodeling program rather than a simple push in one direction, which is consistent with the idea of GHK-Cu as an organizer of repair
K., & Tate, J