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When a knee begins to develop arthritis, changes have been noted in the synovial fluid such that it has a tendency to become less viscous and pro-inflammatory

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Lancet Diabetes Endocrinol 5(4):271279 Wilding JPH, Batterham RL, Davies M, Van Gaal LF, Kandler K, Konakli K, Lingvay I, McGowan BM, Oral TK, Rosenstock J, Wadden TA, Wharton S, Yokote K, Kushner RF, STEP 1 Study Group (2022) Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension

In severe cases, it may cause confusion and loss of consciousness

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