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As no pharmacotherapy for MASLD has been approved at present, lifestyle changes represent the mainstay of therapy

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In particular, LEAP2 (liver-expressed antimicrobial peptide 2), an endogenous antagonist of the ghrelin receptor GHSR, has emerged as a potential target for mitigating the weight regain often observed after discontinuation of GLP-1-based therapies [22,23]

Similar content being viewed by others Background Type 2 diabetes mellitus (T2DM), a common metabolic disorder characterized by insulin resistance and inadequate insulin secretion by pancreatic cells, has become a growing cause of morbidity and mortality worldwide

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