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The BMI requirements mirror semaglutide for the weight management indication

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Studies showed that TGF- induces the expression of the de novo serine [phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1) and phosphoserine phosphatase (PSPH)] and glycine [serine hydroxymethyltransferase 2 (SHMT2)] synthesis pathways in human fibroblasts (225)

Individuals with T2DM and obesity face an elevated risk of various comorbidities, including a fivefold increase in end-stage renal disease, a heightened risk of obesity-related cancers, and a 64% higher likelihood of diabetic retinopathy

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doi:10.4103/1673-5374.390969 92