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Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the SURMOUNT-4 Randomized Clinical Trial
further revealed that functional impairment of the de novo pathway induces premature ovarian ageing: NAD + deficiency triggers ATP synthesis deficiency and ROS overaccumulation by inhibiting OXPHOS complex activity, which in turn induces granulocyte cell cycle arrest (G1/S phase) and mitochondria-dependent apoptotic pathway activation
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Richter G, Feddersen O, Wagner U, Barth P, Goke R, G B