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A 2015 rabbit osteoarthritis model found that intra-articular injection of AOD-9604, particularly combined with hyaluronic acid, improved cartilage integrity and reduced joint degradation

Aghili ZS, Magnani M, Ghatrehsamani M, Nourian Dehkordi A, Mirzaei SA, Banitalebi DM

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Study-related adverse events Adverse reactions reported in 5% of patients and occurring more frequently with Victoza compared with placebo included nausea (21.4% vs 4.4%), vomiting (12.1% vs 2.2%), diarrhea (7.1% vs 2.9%), constipation (5.7% vs 1.5%), increased lipase (15.0% vs 8.8%), GFR decreased (6.4% vs 5.1%), and headache (5.0% vs 2.9%)