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The absolute risk difference is small, but the relative doubling is consistent across multiple trials

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A larger number of the residues in the GLP-2 and glicentin sequence have also accepted amino acid substitutions, with 20 of the 32 sites accepting at least one amino acid substitution in a mammalian species for GLP-2 and 44 of the 69 sites in glicentin being variable, while glucagon and GLP-1 7-37 sequences have substitutions at 11 of 29 and 13 of 31 sites, respectively, and miniglucagon (6 of 11) and OXM (17 of 37) display intermediate levels of variability ( Table 2 , Figure 2 , and Supplementary Figure 5 )