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Watanabe, Fumiko, et al

Proper nutrition also works together with the medication to enhance weight loss effects

These are single molecules engineered to activate two or more distinct receptor systems simultaneously, such as dual GLP-1R/GIPR agonists (e.g., Tirzepatide) or tri-agonists that also target the glucagon receptor

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45,46 As shown in Figure 2 , GLP-1RAs penetrate the blood-brain barrier and directly activate GLP-1 receptors in the hypothalamus, especially within the ARH nucleus, a key center for appetite regulation