Second, we co-expressed GCaMP7s with either human GLP1R or mouse GLP1R in the CeA of Glp1r-Cre mice and recorded calcium transients through fibre photometry (Fig
So knowing that, its not perhaps surprising that there were cardiovascular benefits that were potentially even outside of the degree of weight loss that we see, or the degree of glycemic control that we see, Coviello explained
however, this convenience comes at a cost
For patients, it marks a much-needed shift away from willpower-based narratives and toward understanding weight as something rooted in biology
GLP-1 receptors are located in multiple organs, including the pancreas (to regulate insulin release), the gastrointestinal tract (to control digestion), and the brainstem and hypothalamus (to regulate appetite and nausea)
Dopamine activity is known to be lower in individuals with ADHD, and while the role of serotonin (5-HT) in ADHD has received less attention, the success of medications that primarily affect dopamine suggests that serotonin may be less relevant