MOTS-c treatment enabled 25% of the young C57BL/6J mice to enter the final running stage (highest speed) on a normal diet, but none on a HFD (Fig
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Faccini, Abbott, and Paulus 1990
3 and supplemental Table 3)
More recent studies have reported that complex factors, such as infection, environmental exposures, diabetes and metabolic disorders, and genetics, may all contribute to dementia risk