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Dev Comp Immunol 15(12):3339

Sweilam SH, Ali DE, Atwa AM, Elgindy AM, Mustafa AM, Esmail MM, Alkabbani MA, Senna MM, El-Shiekh RA (2024) A first metabolite analysis of Norfolk Island pine resin and its hepatoprotective potential to alleviate methotrexate (MTX)-induced hepatic injury

These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

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