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During the early stage of repair, inflammatory activation helps clear pathogens and damaged tissue, facilitating the transition from the inflammatory phase to the proliferative phase, thereby promoting the healing process of DFU wounds [38, 41, 42]

Although the biological mechanisms underlying ASD remain largely unknown, previous research has suggested that it may result from changes in brain development early in life, and in particular in relation to GABA, a neurotransmitter, a chemical in the brain that controls how nerve cells communicate

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