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GLP-1 receptor agonists should be considered when patients experience significant weight regain with BMI 27 kg/m with obesity-related comorbidities or BMI 30 kg/m, lifestyle modifications have been insufficient, no anatomical complications require surgical revision, and patients are willing to engage in long-term pharmacotherapy

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CVOT trial will help determine if tirzepatide can demonstrate superior cardiovascular safety and potential additional cardiovascular benefits compared to the currently approved GLP-1RA dulaglutide

How to combine balanced nutrition, exercise, and medication for maximum GLP-1 effectiveness