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Mechanism of action, non-selective activation of the melanocortin system Melanotan II activates all four functional melanocortin receptors (MC1R, MC3R, MC4R, MC5R) with high affinity

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On the other hand, ROS activate NF- B and NLRP3 inflammasomes, upregulating IL-1, IL-18, and TNF-, which sustain systemic inflammation (87)

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