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Abbreviations BMI: Body mass index CV: Cardiovascular CVD: Cardiovascular disease GLP-1Ra: Glucagon-like peptide 1 receptor agonists HF: Heart failure HFmrEF: Heart failure with mildly reduced ejection fraction HFpEF: Heart failure with preserved ejection fraction HFrEF: Heart failure with reduced ejection fraction HHF: Hospitalization for heart failure LV: Left ventricle LVEF: Left ventricular ejection fraction LVMi: Left ventricular mass index NT-proBNP: N-terminal-pro brain natriuretic peptide NNT: Number needed to treat RAAS: Renin angiotensin aldosterone system RCT: Randomized clinical trials SGLT-2i: Sodium glucose transporter 2 inhibitors STEMI: ST-elevation myocardial infarction T2D: Type 2 diabetes References Iribarren C, Karter AJ, Go AS, Ferrara A, Liu JY, Sidney S, Selby JV

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[15] What's even more impressive is that the berberine-treated HFD group actually had a higher serum GLP-1 level than the lean, healthy controls

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