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Research scope includes HPA axis stress modulation (approximately 30% cortisol reduction in human studies), neuroendocrine regulation, and pain modulation

Animal studies also demonstrate its ability to reduce seizure threshold, alleviate depression-like behaviors, and modulate dopaminergic and serotonergic systemseven showing synergy with antidepressants and anxiolytics in preclinical models

It preserves alertness and cognitive performance while reducing anxietya unique pharmacological profile described as an anxiolytic without sedation.Zozulia et al., 2008, PMID 19903495)

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The reasons underlying the bronchoconstricting effect of the glutathione solution are not clear but may be related to sulfite sensitivity since the hypertonic acid solution that served as the placebo resulted in cough in only one subject (213)

Lactate metabolism in human health and disease