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For depression, tirzepatide showed a 65% reduced risk versus 45% for semaglutide

The glyoxalase pathway (consisting of glyoxalase I and glyoxalase II enzymes) for detoxification of methylglyoxal, a cytotoxic molecule, also requires GSH in the first reaction step

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10.1186/s12950-020-00246-4 [DOI] [PMC free article] [PubMed] [Google Scholar] 28.Kauna A, Olczyk P, Komosiska-Vassev K