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The 2024 NICE guideline NG239 sets out a more intensive loading schedule for patients with neurological involvement precisely because their starting point is worse

272 ZhangL.WangY.XiayuX.ShiC.ChenW.SongN.et al (2017)

57,58 Looking forward, large prospective studies are necessary to better elucidate this relationship

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These can include headache, mild gastrointestinal discomfort such as nausea, difficulty sleeping, increased bruising tendency, and changes in mood