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Material and methods Animals The GCLC floxed mice were introduced from The European Mouse Mutant Archive (EMMA)

Peroxisome proliferator-activated receptor alpha (PPARa), a ligand-activated transcription factor of the NR1C nuclear receptor subfamily (alongside PPAR and PPAR/) [18], serves as a master regulator of fatty acid metabolism and lipoprotein genes, while concurrently suppressing pro-inflammatory pathways [19, 20]

10.14309/ajg.0000000000000535 34 GargP

This defense system consists of substances in lower concentrations than oxidizable substrates and can delay or prevent oxidation in the body

Parallel blood aliquots from healthy controls were analyzed using the NADMED assay and two in-house MS methods: LC-MS NADomics 35 and targeted MS-Omics 36