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People taking higher doses, like 2.4 mg or 7.2 mg of Wegovy, typically lose more weight than those on lower doses of injectable or oral Ozempic

The good news

At the starting dose of 0.25 mg, most researchers lose 2 to 6 pounds during the first four weeks

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Last reviewed: May 16, 2026 Last updated: May 16, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

In a clinical trial, patients taking Wegovy at the 2.4mg dose lost around 15 to 17% of their body weight over 68 weeks [1]