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1a) [17]

This work was financially supported by a grant from the National Natural Science Foundation of China (Grant NO

Structural analysis demonstrates how FOXO4-DRI exploits the unique architecture of senescent cells, where FOXO4 latches onto p53 and prevents it from executing its normal pro-apoptotic function

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Authors contributions Writing review & editing, writing original draft (HZ, DW, QW, YWu, ZG, LW, YWang, QZ, LS, BS, GY, WL), formal analysis (HZ), conceptualization (HZ, GY, WL), supervision, and funding acquisition (GY, WL)