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Studies have shown that GLP-1RA administration decreases serum levels of inflammatory cytokines, improves hemodynamic parameters, and reduces mortality ( Figure 2 Figure 3 5 Effects of GLP-1 receptor agonists on biomarkers of inflammation In a systematic review and meta-analysis conducted by Bray et al., data from 40 randomized controlled trials were analyzed to examine the effects of GLP-1RAs on biomarkers of inflammation and oxidative stress in patients with type 2 diabetes

The study also showed a substantial connection between DPP-IV, immune cell infiltration, immune response, and 21 immune checkpoint genes (ICGs) in THCA

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