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It is currently unclear what mechanism underlying the saturation and variability of oral bioavailability of MTX in clinical practice (Murakami and Mori 2012)
CD dogs are considered a suitable animal model for human IVD degeneration because of their spontaneous IVD degeneration, and therefore studies investigating cell-, growth factor-, and/or gene therapy-based regenerative therapies with this model provide information relevant to both human and canine patients
Hence, the blockade of TNF- crucially results in the omission of subsequent pro-inflammatory signaling pathways regulated by subordinate cytokines
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