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Grundke-Iqbal et al., 1986
Potential Interactions and Side Effects Even without direct studies on their combination, we can anticipate potential interactions and exacerbated side effects by examining the known profiles of each drug
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Patients with normal BMI and lymphedema would not be appropriate candidates for these medications, as the risk-benefit profile would be unfavorable without obesity-related indications
432 A 2021 systematic review and meta-analysis that included 22 observational studies with a total of 440,281 elderly participants with atrial fibrillation taking rivaroxaban, dabigatran, apixaban, or edoxaban found these medications were associated with similar reductions in risks of stroke and other embolic events, but rivaroxaban was associated with more bleeding events than apixaban or edoxaban