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J Clin Endocrinol Metab 108, 1937-1946 (2023)

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For example, the combination of metformin and liraglutide is being investigated for both metabolic parameters and fertility outcomes in late-stage clinical trials (Phase III), alongside eight other antidiabetics in Phase III

Metabolic support (glucose control, strength training, zone-2 conditioning when appropriate)

Versus retinol and retinoic acid (cosmetic anti-ageing reference): retinol acts via RAR/RXR receptors and transcriptional modulation but with irritating effects (desquamation, solar sensitivity)