The geroscience model favors such stacked interventions to achieve additive or synergistic effects on healthspan and disease prevention
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Using MSC exosomes or their modified products, or bioactive tissue engineering scaffolds, in combination with GPX4-enhancing small molecules, can promote tissue repair and regeneration while effectively reducing ferroptosis levels in implanted cells or host chondrocytes, thereby improving the survival rate and tissue integration of implants (Singhmar et al., 2025