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Accounting for potential long-term savings due to reducing obesity-related comorbidities ($18.2 billion), net Medicare spending would be $47.7 billion (Table 2, Figure 2, and eFigure 2 in Supplement 1)

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His troponin and brain natriuretic peptide (BNP) levels were unremarkable

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"There was no concern there were any Wada rules being broken

A concrete example that clarifies this boundary is gastrin: multiple adequately powered human trials demonstrated that gastrin-based therapies failed to preserve beta-cell function in type 2 diabetes, and development was largely discontinued by approximately 2010