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We propose that curcumin exerts its broad therapeutic effects via a unified inflammationoxidative stress axis, primarily by inhibiting NF-B and NLRP3 activation, reducing ROS and pro-inflammatory cytokines (TNF-, IL-1/18), as seen across models of depression, metabolic disorders, and neurodegeneration

We checked whether the drugs were solubilised by observing the particles of the drugs using an invert microscope (ECLIPSE Ts2, Nikon Corporation)

These adjustments are vital for individualised therapy

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Repeated measures REML Mixed Models were used to reflect the design and properly compare preparation condition within each subject before amalgamating these comparisons across subjects

Starting at the lowest available dose and advancing slowly allows GI adaptation and early detection of bile-related complications