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While agents such as semaglutide have proven cardiovascular protective effects in large outcome trials [31] , these studies predominantly enrolled patients with established cardiovascular disease or high-risk profiles

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Because the conventional ABDCE criteria used in adults are often inadequate in children, alternative ABCDE criteria that could prevent diagnostic delays have been proposed (Table 1)

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Moreover, the rising prevalence of obesity and type 2 diabetes (T2D) globally continues to significantly boost market demand, as GLP-1 agonists play a pivotal role in the treatment and management of these conditions

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