The key feature of ferroptosis is the accumulation of lipid hydroperoxide, resulting from a decrease in glutathione peroxidases (GPXs)
If you are an active person that engages in moderate- to high-intensity activity, your body quickly burns through its glutathione reserves
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Importantly, pretreatment with ferrostatin-1 and deferoxamine attenuated Apis efficacy on NCI-H929 cells by over threefold, strongly suggesting the potential involvement of ferroptosis-related pathways in Api-mediated MM cell death
Pairing glutathione with vitamin C, NAC, or alpha-lipoic acid can enhance its effects
Our in vitro GSH detection assays also revealed an accumulation of GSH in melatonin treated cells that was not found in vehicle controls