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As GLP-1 therapies such as Semaglutide and Tirzepatide move beyond diabetes management into mainstream obesity treatment, the scale of adoption is unprecedented in India

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In 2023, tirzepatide under the name Zepbound was FDA-approved for obesity as well, after showing ~48 lbs (~22%) mean weight loss over 72 weeks in a trial (SURMOUNT-2) ( [137] )

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Several explanations have been proposed for the discrepancy between the two trials

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