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According to the Summary of Product Characteristics (SmPCs), GLP-1 medications commonly cause nausea (reported in approximately 20-40% of patients with semaglutide and 12-21% with dulaglutide), vomiting, and diarrhoea, particularly during initial treatment and dose escalation
FTO variant is associated with changes in BMI, ghrelin, and brain function following bariatric surgery
This kind of rigorous, data driven analysis is exactly what our field needs to move the conversation from "are NAMs ready?" to "are we benchmarking them fairly?" The bar for NAMs should be high and we are actively advocating for validation guidelines for specific NAMs models
M., Miles, J
PT-141 (bremelanotide) is a more selective MC4R agonist studied in neuro-behavioural arousal models via central melanocortin signalling
