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GLP-1RAs showed significantly more reduction of cardiovascular endpoints than other second- or third-line glucose-lowering medications

Continue to hold the pen against the skin and count to 10

14 A 2017 meta-analysis of 52 randomized, controlled trials that evaluated DPP-4 inhibitors' effects on beta-cell function found that, in monotherapy studies, all agents except linagliptin resulted in improvements in cell function

Because it treats the GLP-1 as one input, not the whole plan

Similar compounds that could bind to GLP-1 receptors but resist inactivation by DDP-4 were researched and found to help treat type 2 diabetes mellitus (T2DM)