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When the transport of dopamine into synaptic vesicles is obstructed or VMAT2 is inhibited by drugs such as tetrabenazine and reserpine, excessive dopamine can accumulate in the cytoplasm, leading to the auto-oxidation of dopamine and the formation of harmful by-products, eventually leading to neurodegeneration

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The dose is typically increased gradually every 4 weeks, progressing from 0.25mg 0.5mg 1mg 1.7mg 2.4mg (maintenance dose)

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These have the correct measurement markings for precision dosing