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doi:10.1007/s13300-018-0454-9.

Similarly, naloxone, a broad opioid receptor antagonist ( 20 ), and cyprodime, an antagonist specific for the -opioid receptor ( 21 ), both significantly reduced nociceptive thresholds in red-haired mice to levels in black mice or to even lower levels at high doses (Fig

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However, chemical peels may potentially induce irritation, burning, and inflammation following treatment, and also may cause melasma relapse (Sheth and Pandya, 2011