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For instance, hypertension has been observed to influence cancer risk, with studies reporting a statistically significant association between hypertension and an increased risk of breast cancer

This hypothesized VEGF/VEGFR interaction may activate a complex intracellular signaling cascade, which may involve multiple proteins such as phospholipase C, protein kinase C, and the mitogen-activated protein kinases

USA 91 , 187191 (1994)

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2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Moher et al., 2009) and the guidelines from the Cochrane Handbook for Systematic Reviews of Interventions (Higgins and Green, 2008)