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A small human study examining the addition of phentermine to liraglutide found no meaningful additional weight loss compared to liraglutide alone

Given that these medications suppress appetite, there is a potential risk for developing disordered eating patterns

Bridges A, Bistas KG, Jacobs TF

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GLP-1 is subsequently rapidly inactivated by dipeptidyl peptidase-4 (DPP-4) with a half-life of 1-3 minutes

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