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The role of cystine in TNBC may be associated with the epithelial-mesenchymal transition (EMT) of cancer cells (7)
19, 20 The latter observation led to a recently completed phase I trial of BSO+L-PAM given with stem cell support in the New Approaches to Neuroblastoma Therapy (NANT) consortium that has safely dose-escalated L-PAM given with BSO to myeloablative L-PAM doses, with the stem cell infusions overcoming the expected hematopoietic toxicity (www.NANT.org
Glutathione is used for skin brightening, anti-aging, detoxification and pigmentation reduction
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Extraction was carried out under chilled conditions with intermittent vortexing to ensure efficient solubilization of metabolites
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