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The study is anticipated to complete in 2025

In addition, drug-metabolizing pathways, especially cytochrome P450, varied significantly across iHLO development, with highly enriched PPAR signaling, a pathway critical for hepatocyte differentiation and lipid metabolism

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Subsequently, innate immune cells in the brain (microglia, astrocytes, and oligodendroglia) are activated in response to inflammatory stimuli including the production of cytokines, chemokines, and secondary inflammatory mediators such as prostaglandins (77)