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The main methods include knocking out essential genes, making engineered bacteria dependent on exogenous nutrients, or setting up suicide switches

For intercellular delivery, once the drug of interest penetrates the SC

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Free vitamin B12 then combines with intrinsic factor a substance secreted by the stomach cellswhich enables it to be absorbed from the small intestine

This will give you a clearer picture of why it has gained so much attention and what the current evidence actually suggests