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Evidence boundary Research on topical copper peptides cannot be transferred automatically to a lyophilised multi-peptide blend

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This study showed that chronic peripheral administration of liraglutide to Phox2b-Cre Glp1r flox/flox mice fed a HFD reduced food intake, body weight, and adiposity suggesting that the PNS is not required for liraglutide to mediate its effects on energy metabolism

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Thus, the basic finding that GLP-1 receptor agonists decrease fluid intake could be especially important in clinical settings, especially with respect to geriatric patient populations that are already at risk for dehydration (6)