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They enhance dopaminergic tone in the mesolimbic pathway, particularly the ventral tegmental area and nucleus accumbens, thereby improving motivational salience and hedonic responsiveness [80,81,92]

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P values of less than 0.05 were considered statistically significant

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The use of NBP and NMP did show a slight reduction in purity compared to DMF, however, the syntheses were still successful in producing the target in relatively high purity with both the wash-based and wash-free conditions