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Previous studies in rodents have also indicated that OB MCs are glucosensitive 32,33

67 A recent cohort study suggests similar efficacy for MTX and MMF between subtypes of CLE, suggesting that other factors such as side-effect profile and comorbid conditions may influence medication selection

While long-term use has not shown safety concerns in available data, cycling helps prevent metabolic adaptation and may maintain the peptides effectiveness across multiple rounds

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It slows gastric emptying, changes appetite signaling, and may influence the gut microbiome