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3.3 Activation of inflammatory pathways ROS can disrupt mitochondrial lipid membrane integrity and lead to mPTP abnormalities, resulting in oxidative damage and leakage of mtDNA (137, 138)

These two properties are thought to be the mechanisms behind L-arginine as an antifibrotic agent (25)

We were specifically interested in the hypothesis that variation in the circulating estrogen level is a determinant of responsiveness to these drugs

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