10.1016/j.bbrc.2022.08.098 110 HalliwellB
Cell viability assay Cell proliferation was detected via a CCK-8 assay (Biosharp, China) or a CellTiter-Glo assay (Promega) according to the manufacturers instructions
Potential Side Effects While rare, some individuals may experience mild side effects when starting MSM
Palpitations accompanied by chest pain or pressure Shortness of breath or difficulty breathing Dizziness, fainting, or near-fainting episodes Rapid or irregular heartbeat lasting more than a few minutes These signs warrant immediate consultation with a healthcare provider
The intranasal route is particularly effective because it delivers the peptide directly to the brain through the olfactory mucosa, bypassing first-pass metabolism and the blood-brain barrier entirely
Compared to GLP-1 Agonists: Weight management peptides like semaglutide and tirzepatide have demonstrated weight loss efficacy superior to AOD-9604 in clinical trials, but they also have distinct side effect profiles