Protocol registration The protocol for this systematic review, focusing on the effect of administering Met and GSH alone and in combination with other compounds on reproductive health and fertility, was registered with PROSPERO (CRD42024561820)
Cathepsin B-sensitive peptide linkers, hyaluronic acid-based nanoparticles, ATP-responsive liposomes and micelles, and 4-Phenylbutyric acid-modified hyaluronic acid-based nanoparticles are engineered to release pharmaceuticals in reaction to enzyme activity, enzymatic degradation by hyaluronidase, elevated ATP levels in metabolically active tumor cells, and esterase activity in 4-PBA-modified hyaluronic acid-based nanoparticles (79)
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Xie et al., 2020
Sirtuin 1 (SIRT1) negatively regulates GH-induced IGF-1 production in the liver by directly inhibiting signal transducer and activator of transcription 5 (STAT5) activation, which causes GH resistance under prolonged fasting, starvation, and malnutrition [6]
