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The gastrointestinal effects are generally dose-dependent, meaning higher doses are associated with increased likelihood and severity of symptoms

Wharton S, Aronne LJ, Stefanski A

The typical tirzepatide maintenance doses for weight loss are 4 mg, 6 mg, 8 mg, 9.5 mg, 11.5 mg and 13.5 mg once weekly

PubMed: 17277604 Maughan RJ, et al

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Administration of D-SIP improves the regulation and production of hormones in these glands by increasing production of LH and GH, while decreasing the production of undesirable ones like cortisol and somatostatin